TOPICAL PROTEASE INHIBITOR INCREASES TUMOR-FREE AND OVERALL SURVIVAL IN CD4-DEPLETED MOUSE MODEL OF ANAL CANCER

Patients with immunodeficiencies and older age are at an increased risk of anal cancer.Transgenic K14E6/E7 mice with established high-grade anal dysplasia were treated topically at the anus with the protease inhibitor saquinavir (SQV) in the setting of CD4+ T-cell depletion to mimic immunodeficiency.To ensure tumor development, specific groups were

In this study the numeric computations of nonstationary heat Pedestal Fans flow in form of temperature distribution on characteristic surfaces of the piston of the turbocharged engine at the beginning phase its work was presented.The computations were performed for fragmentary load engine by means of the two-zone combustion model, the boundary cond